In an attempt to evaluate the effect of high and low concentration of Injinsaryungsan and high and low concentration of Sosihotang on cholestatic liver injery induced by AMT(α-naphthylisothiocyanate), biochemical changes in serum transaminase(GOT, GPT), alkaline phosphate, lactate dehydrogenase, total cholesterol, triglyceride, total-bilirubine were studied and the following results were obtained.
1. High concentration of Injinsaryungsan(2.2g/Kg) inhibited significantly the activity increases of GOT, GPT, ALP, LDH, TC, TG, T-Bilirubine induced by AMT(α-naphthylisothiocyanate).
2. Low concentration of Injinsaryungsan(1.1g/Kg) inhibited the activity increases of ALP, LDH, TC, TG with statistical significance, while inhibited the activity increase of GOT but with no statktical significance.
3. High concentration of Sosihotang(2.4g/Kg) inhibited the activity increases of LDH, TG, TC with statistical significance while inhibited the activity increases of GOT, GPT, ALP, T-bilirubine with no Significance.
4. Low concentration of Sosihotang(1.2g/Kg) inhibited the activity increase of TG, while inhibited the activity increase of ALP, TC with no statistical sig-nificance, but didn´t inhibite the activity increases of GOT, GPT, LDH, T-Bil.
These results suggest that Injinsaryungsan has more significant effect on the liver injury induced by AM I´(a-naphthylisothiocyanate) compared with Sosihotang and so can be applicable clinically to virus h:-patitis and-,cholestatic liver injury. Further study will be required to evaluate the effect of Sosihotang on cholangitis and cholecystitis.
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